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KMID : 0545120070170091546
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Journal of Microbiology and Biotechnology
2007 Volume.17 No. 9 p.1546 ~ p.1549
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Chemopreventive Effect of Chitosan Oligosaccharide Against Colon Carcinogenesis
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Nam Kyung-Soo
Kim Mee-Kyung
Shon Yun-Hee
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Abstract
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Chitosan oligosaccharide (COS, 3 kDaQR activity in a dose-dependent manner over a concentration range of 0.1-4.0 mg/ml. GST activity was also induced in
HT-29 cells treated with COS. In addition, GSH levels were increased 1.3-, 1.4-, and 1.5-fold with COS at 2, 3, and 4 mg/ml, respectively. ODC activity induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA) was inhibited by 33% and 39% with 3 and 4 mg/ml of COS, respectively. COS also inhibited the expression of TPA-induced COX-2 protein in HT-29 cells. These results suggest that COS has colon cancer chemopreventive activity by increasing QR and GST activities and GSH levels and by inhibiting ODC activity and COX-2 expression in vitro.
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KEYWORD
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Chitosan oligosaccharide, colon cancer, cyclooxygenase, glutathione S-transferase, ornithine decarboxylase, quinone reductase
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